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Multiple attacks killed at least 100 people and wounded 78 others in Sweida and villages northeast of the Syrian city, the head of the health authority told state-run Ikhbariyah TV.
A suicide bomber blew himself up near a marketplace in the city early on Wednesday, as Daesh terrorists mounted attacks on several villages to the northeast.
State media said authorities were hunting down terrorists in the city.
Daesh said in a statement that it had carried out the attacks.
the seemingly coordinated attacks were the deadliest to hit government territory in many months.
Northeast of Sweida city, Daesh launched simultaneous attacks on several villages where they clashed with government forces, state media and the Observatory said.
In the city itself, at least two attackers blew themselves up, one near a marketplace and the second in another district, state television said. State news agency SANA said two other Daesh terrorists were killed before they could detonate their bombs.